Subject
Diabetes mellitus is considered as one of the oldest NCDs recorded in the Egyptian manuscript approximately around 3000 years ago, can be categorised into two broad types- T1DM and T2DM. T2DM marks as the most common occurring form and is considered as a major cause of morbidity and mortality throughout the world. It is a complex process where interplay of gene and environment explain the pathogenesis of this disorder. In addition to that, fat patterning in terms of obesity have concomitant effect on T2DM.
Objectives
Since, Inter-Ethnic variations are found in the allele frequency of CAPN10 gene and the study on north-east Indian population is limited therefore, the present study attempted to discern the association of fat patterning, Type 2 Diabetes Mellitus and CAPN10 Gene Polymorphism on the Karbi females of North East India (Assam). For this, a total of 76 apparently healthy adult females were incorporated. Anthropometric and physiological variables (blood sugar) have been collected using standard techniques. Extracted genomic DNA from mouthwash (Standard protocol) was PCR amplified and genotyped for CAPN10 gene polymorphism.
Academic or Practical Relevance to the Anthropological Science
The studied population is characterised by higher prevalence of “I” allele which means they are genetically predisposed to develop T2DM but according to fat patterning they are not obese which may be working as a savour and restricts the increase of T2DM among the Karbi individuals but if their lifestyle factors changed, they have potential risk of developing this. Besides, those who have comparatively higher level of Blood glucose level characterize by “I” allele which means “I” allele can be use as diagnostic biomarker of T2DM. This result will help to take relevant measures for early prevention and treatment. Beside this, Anthropological Genetics will help in developing Precision medicine.
