<p><strong>Background</strong>: Many Ethiopians use traditional medicines sold in open-air markets. However, little is known about the role of these alternative medicines in preventing and treating COVID-19. <strong>Objectives</strong>: The objectives of this study are to identify medicinal plants and plant products sold by vendors in the markets of Gondar City and used by their clients to treat the COVID-19-related symptoms of fever, cough, and headache. <strong>Methods and Materials</strong>: Questionnaires were used to interview vendors and clients. Results: The research identified 38 vendors who sold traditional medicines and 37 clients who reported using medicines for fever, cough, and headache. Of the 14 medicinal, food, and spice plants and plant products sold, the most common were garlic (<em>Allium sativum</em>) followed by black cumin (<em>Nigella sativa</em>) seeds, <em>haregresa </em>(<em>Zehneria scabra</em>) leaves, and basil (<em>Ocimum trifolium</em>) leaves. The plant materials most commonly used were <em>haregresa</em> leaves, garlic, and flax seeds. Four of the plants have active anti-coronavirus, anti-tussive, immune-modulatory, and anti-inflammatory compounds. Conclusion: Open-air markets are a major source of indigenous foods and medicines that may be valuable in the management of COVID-19. Medicinal plant products sold for fever, headache, and cough in Gondar City may have mostly palliative and immuno-modulatory benefits. Several areas needin<a name="_Toc516604132"></a><a name="_Toc10861527"></a><a name="_Toc10861910"></a><a name="_Toc10862232">g further study are identified.</a></p>
