<p>In Ecuador, the indigenous population is about 1.1 million people, 24.1 % of whom live in the Amazon, in the eastern region, and belong to 10 nationalities. In the country, indigenous peoples have historically suffered structural and systematic discrimination. Recently, due to the expansion of extractive activities that threaten their territories, socio-ecological conflicts against the exploitation of the environment and the violation of their rights have increased. These issues were exacerbated during the COVID-19 pandemic, leading to an exponential growth of the vulnerability and marginality they face. Based on digital ethnography and in-depth interviews, I aim to analyze the impact of the pandemic on the lives of the indigenous peoples of the Ecuadorian Amazon, and what kind of strategies they have put into practice to cope with the increasingly critical problems. It is a question of great academic and practical relevance, in order to shed light on their health conditions and the violations of their rights that occurred during the pandemic. In this sense, although the neglect and absence of the Ecuadorian state in meeting the basic needs of the communities has been significant, they have put into practice resilient actions based on cooperation and reciprocity to mitigate the damage caused by the growing contagions. Finally, with regard to the concept of intersectionality, I aim to highlight how indigenous women were the most affected subjectivities who, in the specificity of the emergency, found themselves in a position of greater vulnerability.</p>