The COVID-19 pandemic transformed world history. In the second dedace of the 21 st century, an event changed the course of humanity. The consequences of the SARS-CoV-2 virus were seen worldwide. It was in December 2019, in the population of Wuhan China, where a new virus emerged that was called SARS-CoV-2.This new disease was declared a pandemic by the WHO on March 11, 2020. This disease would collapse health systems since not only Asian or European countries suffered from the COVID-19 pandemic, but also Africa and America, such a situation generated fear and uncertainty around the world.The global impact was catastrophic due to the loss of human life. In Mexico, the effects were shocking, and particularly, in Guerrero the most vulnerable and low-income groups were the ones who suffered the effects. In particular, the population is located in the indigenous regions.The indigenous peoples were drastically hit by the arrival of the pandemic since, being communities with difficult access, health services are not close. In addition, the lack of information was a barrier that prevented them from taking preventive measures. This population took its own sanitary measures, such as controlling access to the entrances to the communities, resorting to traditional medicine, drinking drinks with plants and also installing checkpoints, and not allowing entry of people outside the community.The research carried out is called "Vaccination against SARS-CoV-2 in Indigenous Women of reproductive age" and consisted of conducting a study with one of the most vulnerable sectors in the context of adversity. Women of reproductive age, due to their condition, were the most prone to any outbreak of infectious diseases.