Nigerians have been the largest African group in Guangzhou, China. Although the epidemic has prevented largely the population movement between China and Nigeria, there are still a significant number of long-term Nigerian residents in Guangzhou. Before the outbreak of the epidemic, they were mainly engaged in import and export trade and logistics in China. During the epidemic, their business declined. Some returned Nigeria, and some struggled to maintain their work and life in Guangzhou. The authors conducted questionnaire surveys and interviews with Nigerians in Guangzhou pre, during and after the epidemic, and discussed the obstacles and strategies for Nigerians' adaptation in China. From the study, language is identified as the primary difficulty for cross-cultural adaptation. However, more difficulties come from foreigners lack of access to public service and social welfare, including employment security, business subsidies, and access to public health care system in particular. The lack of social security makes it hard for Nigerian residents to maintain their income and even created difficulties for them in making an everyday living in Guangzhou. In view of cross-cultural adaptation strategies, ethnic and religious identity are important aspects of Nigerian cultural identity and play important roles in the cross-cultural adaptation. Though the onsite aggregation is limited for ethnic and religious activities, online activities connected Nigerians with relatives, friends, and business partners in home country, in China and even globally, and create social networks and supports for Nigerian residents in Guangzhou. In terms of social management, though multiculturalism is not evidently adopted in China, China needs to enhance capability for promoting the integration of foreigners, no matter from the aspects of the economy, politics, society and culture.