An unforeseen and challenging new age for humanity has begun due to the COVID-19 pandemic. To address this challenge, WHO suggested guidelines that doctors were required to follow when treating patients in the pandemic, even though those didn’t reflect local knowledge or practices. As Bangladesh's healthcare structure is not identical to that of the “West”, while implicating those guidelines, they had to go through a bunch of new realities. This article will focus on the rationality and consequences of implicating those initiatives locally and on doctors’ experiences. A multi-sited ethnographic approach was used in this study, as well as netnography, online and physical interviews, and case studies as research methods. The findings of this study revealed that while healthcare authorities forced the doctors to follow western based guidelines, several structural challenges were faced due to low and old health care equipment, inadequate safety equipment, a shortage of healthcare providers, and poor health service management. Bangladeshi doctors encountered high levels of work stress, separation from family, and uncertainty about their lives, which damaged their mental and physical health. Furthermore, as they physically serve individuals, they are referred to as COVID-19 carriers, which has alienated them from society. Therefore, the doctors have also been encountering and negotiating with several unprecedented situations and social stigmas since the contamination has seen an upturn. Doctors were prescribing medicines following those guidelines, but the negligence of herbal remedies and local treatment resulted in less fruitful treatment results. Moreover, due to financial and global politics, Bangladesh couldn’t get an adequate vaccine initially. From the critical approach, the proliferation of biomedicine over the local herbal remedies, practices, and western-imposed regulations results in Bangladeshi healthcare structures failure, and general people aim at the doctors for this situation, which is a consequence of the global healthcare structure’s inequalities.