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Authors Information
SequenceTypeName TitleFirst NameLast NameDepartmentInstitute / Affiliation
1 Author Dr. Pranabesh Sarkar School of Forensic Sciences, The West Bengal National University of Juridical Sciences Faculty
2 Author Dr. Diptendu Chatterjee Department of Anthropology ,University of Calcutta Associate Professor
3 Author Prof. Arup Ratan Bandyopadhyay Department of Anthropology ,University of Calcutta Professor
Abstract Information
TrackID
:
IUAES23_ABS_O3687
Abstract Theme
:
P132 - Anthropological perspectives in human evolution and biological variation in Asia
Abstract Title
:
Association of MTHFR (rs1801133) and FTO (rs9939609) genetic polymorphisms and obesity in T2DM: A study among Bengalee Hindu caste population of West Bengal, India
Short Abstract
:
The present work is attempted to understand the association of methylenetetrahydrofolate reductase (MTHFR) (rs1801133) and FTO (rs9939609) genetic polymorphisms and obesity with T2DM among the Bengalee Hindu caste population of West Bengal, India. MTHFR (rs1801133) genetic polymorphism with CT genotype revealed significantly higher risk (OR= 3.44; p = .01) of T2DM compared to the CC genotype. The attenuation of MTHFR-T2DM risk after adjustment for age and waist circumference revealed obesity and age effects in progression of T2DM. T2DM patients also had significantly (p < .05) higher overall obesity, central obesity, and SBP compared to the controls. However, FTO (rs9939609) genetic polymorphism demonstrated no significant (p= .854) effect on T2DM and obesity.
Long Abstract
:

Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder characterized by high blood glucose levels or hyperglycaemia due to defects in insulin secretion from pancreatic β cells and peripheral insulin resistance. T2DM susceptibility has increased due to the independent risks of genetic polymorphism and obesity as well as combinations of both. Despite recent advancements in T2DM management and diagnosis, the challenges of susceptibility and prognosis still remain persists. The present work is attempted to understand the association of methylenetetrahydrofolate reductase (MTHFR) (rs1801133) and FTO (rs9939609) genetic polymorphisms and obesity with T2DM among the Bengalee Hindu caste population of West Bengal, India. One hundred and four clinically diagnosed T2DM male patients and 176 healthy males, without family history of T2DM, (control group) of the endogamous linguistic group (Bengalee Hindu caste) participated. PCR-RFLP method was used for genotyping after the isolation of genomic DNA. MTHFR (rs1801133) genetic polymorphism with CT genotype revealed significantly higher risk (OR= 3.44; p = .01) of T2DM compared to the CC genotype. The attenuation of MTHFR-T2DM risk after adjustment for age and waist circumference revealed obesity and age effects in progression of T2DM. T2DM patients also had significantly (p < .05) higher overall obesity, central obesity, and SBP compared to the controls. However, FTO (rs9939609) genetic polymorphism demonstrated no significant (p= .854) effect on T2DM and obesity. The present study identified that MTHFR genetic polymorphism and obesity might be used as screening tools for early prognosis of T2DM.
Abstract Keywords
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MTHFR, Obesity, T2DM, Bengalee Hindu Caste.